Journal:
Nat Struct Mol Biol.
Publication Date:
Mon, 2019-09-16
Institutions:
1 UCSF Diabetes Center, San Francisco, CA, USA. 2
Eli and Edythe Broad Center of Regeneration Medicine
and Stem Cell Research, San Francisco, CA, USA.
3 Department of Cell and Tissue Biology, University of
California, San Francisco, CA, USA.
Abstract:
Beige fat serves as a substantial metabolic sink that dissipates energy and has consequently attracted much
attention as a target for improving metabolic health. A recent study has provided a new molecular target, the
N-terminal acetyltransferase Naa10p, for harnessing beige-fat biogenesis and improving whole-body energy
homeostasis.