Pubs

Publications


2017

UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis
Kenji Ikeda, Qianqian Kang, Takeshi Yoneshiro, Joao Paulo Camporez, Hiroko Maki, Mayu Homma, Kosaku Shinoda, Yong Chen, Xiaodan Lu, Pema Maretich, Kazuki Tajima, Kolapo M Ajuwon, Tomoyoshi Soga & Shingo Kajimura
Nature Medicine. | Monday, November 13, 2017

Obesity-linked phosphorylation of SIRT1 by CK2 inhibits its nuclear localization 2 and promotes fatty liver
SungE Choi, Sanghoon Kwon, Sunmi Seok, Zhen Xiao, Kwan-Woo Lee, Yup Kang, Xiaoling Li, Kosaku Shinoda, Shingo Kajimura, Byron Kemper and Jongsook Kim Kemper
Molecular and Cellular Biology. | Monday, May 22, 2017

Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling
Ambre M. Bertholet, Lawrence Kazak, Edward T. Chouchani, Marta G. Bogaczynska, Ishan Paranjpe, Gabrielle L. Wainwright, Alexandre Be´tourne´, Shingo Kajimura, Bruce M. Spiegelman, and Yuriy Kirichok
Cell Metabolism | Tuesday, April 4, 2017

Mitochondrial homeostasis in adipose tissue remodeling
Altshuler-Keylin S & Kajimura S
Science Signaling. | Tuesday, February 28, 2017

Mammary alveolar epithelial cells convert to brown adipocytes in post-lactating mice
Giordano A, Perugini J, Kristensen DM, Sartini L, Frontini A, Kajimura S, Kristiansen K, Cinti S
Cell Physiol. | Sunday, February 12, 2017

Adipose tissue in 2016: Advances in the understanding of adipose tissue biology
Kajimura S
Nat Rev Endocrinol. | Wednesday, January 4, 2017

2016

PDGFA Makes Thin Skin Thicker: Molecular Regulation of Adipose Progenitor Maintenance
Kajimura S
Cell Stem Cell. | Thursday, December 1, 2016

Mitochondrial Activity in Human White Adipocytes Is Regulated by the Ubiquitin Carrier Protein 9/microRNA-30a Axis
Koh EH, Chen Y, Bader DA, Hamilton MP, He B, York B, Kajimura S, McGuire SE, Hartig SM
J Biol Chem. | Friday, November 18, 2016

Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance
Altshuler-Keylin S, Shinoda K, Hasegawa Y, Ikeda K, Hong H, Kang Q, Yang Y, Perera RM, Debnath J, Kajimura S
Cell Metab | Wednesday, August 24, 2016

Transcriptional and epigenetic control of brown and beige adipose cell fate and function
Inagaki T, Sakai J, Kajimura S.
Nat Rev Mol Cell Biol. | Wednesday, August 17, 2016

Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans
Chondronikola M, Volpi E, Børsheim E, Porter C, Saraf MK, Annamalai P, Yfanti C, Chao T, Wong D, Shinoda K, Labbė SM, Hurren NM, Cesani F, Kajimura S, Sidossis LS.
Cell Metab. | Tuesday, June 14, 2016

A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function
Svensson KJ, Long JZ, Jedrychowski MP, Cohen P, Lo JC, Serag S, Kir S, Shinoda K, Tartaglia JA, Rao RR, Chédotal A, Kajimura S, Gygi SP, Spiegelman BM.
Cell Metabolism | Tuesday, March 8, 2016

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer
Camarda R, Zhou AY, Kohnz RA, Balakrishnan S, Mahieu C, Anderton B, Eyob H, Kajimura S, Tward A, Krings G, Nomura DK, Goga A.
Nature Medicine | Monday, March 7, 2016

A synergistic anti-obesity effect by a combination of capsinoids and cold temperature through promoting beige adipocyte biogenesis
Ohyama K, Nogusa Y, Shinoda K, Suzuki K, Bannai M, Kajimura S.
Diabetes | Wednesday, March 2, 2016

Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky DJ et al.
Autophagy | Thursday, January 21, 2016

2015

Phosphoproteomics Identifies CK2 as a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure
Shinoda K, Ohyama K, Hasegawa Y, Chang HY, Ogura M, Sato A, Hong H, Hosono T, Sharp LZ, Scheel DW, Graham M, Ishihama Y, Kajimura S.
Cell Metabolism | Tuesday, December 1, 2015

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat
Kazak L1, Chouchani ET1, Jedrychowski MP2, Erickson BK2, Shinoda K3, Cohen P1, Vetrivelan R4, Lu GZ5, Laznik-Bogoslavski D5, Hasenfuss SC1, Kajimura S3, Gygi SP2, Spiegelman BM6.
Cell | Thursday, October 22, 2015

Comparative analysis of microRNA expression in mouse and human brown adipose tissue
Isabelle Güller, Sarah McNaughton, Tamsyn Crowley, Vicente Gilsanz, Shingo Kajimura, Matthew Watt and Aaron P. Russell
BMC Genomics | Monday, October 19, 2015

Brown and Beige Fat: Physiological Roles beyond Heat Generation
Kajimura S, Spiegelman BM, Seale P.
Cell Metabolism | Tuesday, October 6, 2015

JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis
Yohei Abe, Royhan Rozqie, Yoshihiro Matsumura, Takeshi Kawamura, Ryo Nakaki, Yuya Tsurutani, Kyoko Tanimura-Inagaki, Akira Shiono, Kenta Magoori, Kanako Nakamura, Shotaro Ogi, Shingo Kajimura, Hiroshi Kimura, Toshiya Tanaka, Kiyoko Fukami, Timothy F. Osborne, Tatsuhiko Kodama, Hiroyuki Aburatani, Takeshi Inagaki & Juro Sakai
Nature Communications | Thursday, May 7, 2015

Genetic and functional characterization of clonally derived adult human brown adipocytes
Shinoda K, Luijten IHN, Hasegawa Y, Hong H, Sonne SB, Xue R, Chondronikola M, Kim M, Cypess AM, Tseng Y, Nedergaard J, Sidossis LS, & Kajimura S.
Nature Medicine | Tuesday, April 21, 2015

Regulation of systemic energy homeostasis by serotonin in adipose tissues
Chang-Myung Oh, Jun Namkung, Younghoon Go, Ko Eun Shong, Kyuho Kim, Hyeongseok Kim, Bo-Yoon Park, Ho Won Lee, Yong Hyun Jeon, Junghan Song, Minho Shong, Vijay K. Yadav, Gerard Karsenty, Shingo Kajimura, In-Kyu Lee, Sangkyu Park, and Hail Kim
Nature Communications | Monday, April 13, 2015

A combination of exercise and capsinoid supplementation additively suppresses diet-induced obesity by increasing energy expenditure in mice
Ohyama K, Nogusa Y, Suzuki K, Shinoda K, Kajimura S, Bannai M
American Journal of Physiology: Endocrinology and Metabolism | Sunday, February 15, 2015

Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis
Sidossis L & Kajimura S.
J Clin Invest. | Monday, February 2, 2015

2014

Lightening up a notch: Notch regulation of energy metabolism
Thomas Gridley & Shingo Kajimura
Nature Medicine | Wednesday, August 6, 2014

ThermoMouse: an in vivo model to identify modulators of UCP1 expression in brown adipose tissue
Galmozzi A, Sonne SB, Altshuler-Keylin S, Hasegawa Y, Shinoda K, Luijten IH, Chang JW, Sharp LZ, Cravatt BF, Saez E, & Kajimura S.
Cell Reports | Thursday, December 11, 2014

Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch
Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM
Cell | Thursday, January 16, 2014

2013

EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex
Ohno, H., Shinoda, K., Ohyama, K., Sharp, L.Z. & Kajimura, S.
Nature | Wednesday, November 6, 2013

A New Era in Brown Adipose Tissue Biology: Molecular Control of Brown Fat Development and Energy Homeostasis
Kajimura S and Saito M
The Annual Review of Physiology | Monday, November 4, 2013

Relevance of brown adipose tissue in infancy and adolescence
Gilsanz, V., Hu, H.H., Kajimura, S.
Pediatric Research | Monday, June 24, 2013

Isolation and differentiation of stromal vascular cells to beige/brite cells
Aune UL, Ruiz L, Kajimura S.
J. Vis. Exp. | Thursday, March 28, 2013

2012

Regulation of Early Adipose Commitment by Zfp521
Sona Kang, Peter Akerblad , Riku Kiviranta , Rana K. Gupta, Shingo Kajimura, Michael J. Griffin, Jie Min, Roland Baron, Evan D. Rosen
PLOS Biology | Tuesday, November 27, 2012

Human BAT possesses molecular signatures that resemble beige/brite cells
Sharp, L.Z., Shinoda, K., Ohno, H., Scheel, D.W., Tomoda, E., Ruiz, L., Hu, H., Wang, L., Pavlova, Z., Gilsanz, V., Kajimura, S.
PLOS ONE | Friday, November 16, 2012

A novel therapeutic approach to treating obesity through modulation of TGFβ signaling
Koncarevic A, Kajimura S, Cornwall-Brady M, Andreucci A, Pullen A, Sako D, Kumar R, Grinberg AV, Liharska K, Ucran JA, Howard E, Spiegelman BM, Seehra J, Lachey J
Endocrinology | Tuesday, May 1, 2012

PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein
Ohno H, Shinoda K, Spiegelman BM, Kajimura S.
Cell Metabolism | Wednesday, March 7, 2012

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM.
Nature | Wednesday, January 11, 2012

2011

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
Seale P, Conroe HM, Estall J, Kajimura S, Frontini A, Ishibashi J, Cohen P, Cinti S, Spiegelman BM.
J Clin Invest. | Tuesday, January 11, 2011

2010

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5
Choi JH, Banks AS, Estall JL, Kajimura S, Boström P, Laznik D, Ruas JL, Chalmers MJ, Kamenecka TM, Blüher M, Griffin PR, Spiegelman BM.
Nature | Thursday, July 22, 2010

Transcriptional control of brown fat development
Kajimura S, Seale P, Spiegelman BM.
Cell Metabolism | Wednesday, April 7, 2010

2009

Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex
Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, Gygi SP, Spiegelman BM.
Nature | Thursday, August 27, 2009

Transcriptional control of brown adipocyte development and physiological function--of mice and men
Seale P, Kajimura S, Spiegelman BM
Genes and Development | Wednesday, April 1, 2009

2008

PRDM16 controls a brown fat/skeletal muscle switch
Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scimè A, Devarakonda S, Conroe HM, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM.
Nature | Thursday, August 21, 2008

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex
Kajimura S, Seale P, Tomaru T, Erdjument-Bromage H, Cooper MP, Ruas JL, Chin S, Tempst P, Lazar MA, Spiegelman BM.
Genes and Development | Thursday, May 15, 2008

2007

Transcriptional control of brown fat determination by PRDM16
Seale P*, Kajimura S*, Yang W, Chin S, Rohas LM, Uldry M, Tavernier G, Langin D, Spiegelman BM.
Cell Metabolism | Friday, July 6, 2007



Featured Publications


2016

Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance
Altshuler-Keylin S, Shinoda K, Hasegawa Y, Ikeda K, Hong H, Kang Q, Yang Y, Perera RM, Debnath J, Kajimura S
Cell Metabolism 24(3):402-19. PMC5023491 | Wednesday, August 24, 2016
[Research highlight in Cell Metabolism 2016; Nature Reviews Endocrinology2016]

2015

Phosphoproteomics Identifies CK2 as a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure
Shinoda K, Ohyama K, Hasegawa Y, Chang HY, Ogura M, Sato A, Hong H, Hosono T, Sharp LZ, Scheel DW, Graham M, Ishihama Y, Kajimura S.
Cell Metabolism 22(6):997-1008 | Tuesday, December 1, 2015
[Research highlight in Cell Metabolism 2015]

Genetic and functional characterization of clonally derived adult human brown adipocytes
Shinoda K, Luijten IHN, Hasegawa Y, Hong H, Sonne SB, Xue R, Chondronikola M, Kim M, Cypess AM, Tseng Y, Nedergaard J, Sidossis LS, & Kajimura S.
Nature Medicine 21(4):389-94. PMC4427356 | Tuesday, April 21, 2015
[Research highlight in Nature Medicine 2015]

2014

ThermoMouse: an in vivo model to identify modulators of UCP1 expression in brown adipose tissue
Galmozzi A, Sonne SB, Altshuler-Keylin S, Hasegawa Y, Shinoda K, Luijten IH, Chang JW, Sharp LZ, Cravatt BF, Saez E, & Kajimura S.
Cell Reports S2211-1247. PMC4268417| Thursday, December 11, 2014
[Research highlight in Nature Biotech 2014; Biotechnology2014; Selected in Faculty1000]

2013

EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex
Ohno, H., Shinoda, K., Ohyama, K., Sharp, L.Z. & Kajimura, S.
Nature 504(7478):163-67. PMC3855638| Wednesday, November 6, 2013
[Research highlight in Cell Metabolism 2014, Selected in Faculty1000, NIH director's blog]

2012

PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein
Ohno H, Shinoda K, Spiegelman BM, Kajimura S.
Cell Metabolism 15(3), 395-404. PMC2410936 | Wednesday, March 7, 2012