Obesity is a major risk factor for metabolic disorders such as type-2 diabetes. Adipose tissues can regulate energy homeostasis in response to a variety of environmental and genetic factors by the secretion of various adipokines and by adaptive thermogenesis.
The main focus of our lab is to uncover the molecular circuits that control adipose cell development and function by employing a wide range of molecular biology, developmental biology and biochemical approaches together with mouse genetics.
Our goals are to uncover the various transcriptional and epigenetic networks that regulate brown fat cell development and maintenance and to determine the role of brown fat in controlling energy homeostasis. We hope these studies will translate to the development of novel therapies for various metabolic disorders.